Research Scientist
RESEARCH SCIENTIST, BIOMARKERS
Denali Therapeutics is dedicated to developing breakthrough therapies for patients with neurodegenerative disease through deep commitment to understanding degeneration biology and rigorously applying the principles of translational medicine.
The Opportunity
Denali Therapeutics is seeking a motivated laboratory-based Research Scientist to join our Translational Sciences group and support the company’s growing translational biology and biomarker needs. This individual will help implement biomarker assays for preclinical target engagement studies by working in close collaboration with colleagues in other teams such as In Vivo, Research, Development Sciences, and Clinical Development. This scientist would also contribute towards discovery and development of novel biomarkers for target engagement assessment. This position will focus on diseases relevant to lysosomal dysfunction and lysosomal pathways.
Responsibilities:
- Work under supervision of Denali senior scientists to conduct biomarker research in a dynamic, highly collaborative and fast-paced environment.
- Design and conduct in vivo and in vitro biomarker assays, including plate-based immunoassays and functional cell-based assays to measure readouts of lysosomal pathways and target engagement in preclinical and clinical biosamples.
- Coordinate with computational biologists and statisticians to analyze data and report quantitative results.
- Create assay controls and reagents for internal and clinical use as needed.
- Archive, process, track and test large sets of biosamples from preclinical and clinical studies.
- Work in collaboration with the automation team to analyze large biosample sets for preclinical and clinical studies.
- Maintain detailed records of the experimental procedures and data in accordance with Denali policy.
- Communicate experimental designs, assay validation plans, protocols, and biomarker data to cross-functional teams and collaborators.
- Stay up-to-date with research on biomarkers in neurodegenerative diseases and immunoassay technologies.
Requirements
- A Bachelors or preferrably Masters degree with in biology, neuroscience, cell biology or immunology.
- Extensive experience in molecular, biochemical, and cellular techniques including mammalian cell culture, western blotting, qPCR, FACS, or plate-based immunoassays. Experience with laboratory automation is a plus.
- Outstanding organizational and communication skills with the ability to work independently in a collaborative, dynamic and fast paced environment.
- Strong project planning and time management skills, and the ability to multitask to meet tight project deadlines.
- Creative and inquisitive scientific thinker who is eager to explore and learn new techniques.