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FDA Postdoctoral Research Fellowship in Molecular and Genetic Toxicology

*Applications will be reviewed on a rolling-basis.

A postdoctoral fellowship opportunity is currently available in the Division of Molecular and Genetic Toxicology, National Center for Toxicological Research (NCTR) of the U.S. Food and Drug Administration (FDA) Jefferson Laboratories Campus located in Jefferson, Arkansas.

The majority of drugs administered during pregnancy lack appropriate information on embryo/fetal safety. To address this FDA regulatory need, the selected participant will use a model that combines human embryonic stem cells (hESCs) as an in vitro surrogate of the developing embryo with a placental barrier to evaluate the risks associated with placental drug transfer. Collaborative activities include: 1) differentiating hESCs into cardiomyocytes or neurons for use in evaluating risks associated with placental drug transfer, and measuring a panel of general toxicity and cardiac- and neuro- developmental toxicity endpoints; 2) following completion of toxicology studies, analyzing gene expression and epigenetic profiles as well as mutation induction in response to drug exposure and identify sensitive biomarkers of embryo-fetal toxicity. The participant will collaborate with FDA investigators at NCTR and with investigators in other FDA centers. During the project, the participant will be actively encouraged to present the research at internal and external meetings and publish the findings in peer-reviewed journals.

Anticipated Appointment Start Date: Spring 2021

This program, administered by ORAU through its contract with the U.S. Department of Energy to manage the Oak Ridge Institute for Science and Education, was established through an interagency agreement between DOE and FDA. The initial appointment is for one year, but may be renewed upon recommendation of FDA contingent on the availability of funds. The participant will receive a monthly stipend commensurate with educational level and experience. Proof of health insurance is required for participation in this program. The appointment is full-time at FDA in the Jefferson, Arkansas, area. Participants do not become employees of FDA, DOE or the program administrator, and there are no employment-related benefits.

If you have questions, send an email to ORISE.FDA.NCTR@orau.org. Please include the reference code for this opportunity in your email.